Professor of Medicine and Physiology
Senior Associate Dean for Research, Medical College of Wisconsin

Positions and Employment
1980-1982  Resident, Dept Int Med, Univ of Iowa College of Medicine, Iowa City, IA
1982-1986 Fellow, Dept Int Med, Univ of Iowa College of Medicine, Iowa City, IA
1983-1984 Chief Resident, Dept Int Med, University of Iowa College of Med, Iowa City, IA
1986-1987 Associate, (non-tenured), Dept Int Med, Univ of Iowa College of Med, Iowa City, IA
1987-1992Assistant Professor (non-tenured), Dept Int Med, Univ of Iowa Col Med, Iowa City, IA
1992-1998 Associate Professor (tenured), Dept Int Med, Univ of Iowa College of Med, Iowa City, IA
1998Professor (tenured), Dept Int Med, Univ of Iowa College of Med, Iowa City, IA
1998 Professor, Dept Int Med and Physiology, Medical College of Wisconsin, Milwaukee, WI
2000  Northwestern Mutual Professor of Cardiology, Medical College of Wisconsin, Milwaukee, WI
2004  Professor, Dept of Pharmacology/Toxicology, Medical College of Wisconsin, Milwaukee, WI
2005 Senior Associate Dean for Research, Medical College of Wisconsin, Milwaukee, WI

Other Experience and Professional Memberships

1997-1999 Chairman, AHA Affiliate Review Committee
1999 Associate Editor, American Journal of Physiology – Heart and Circulation
2000 Circulation Research, Editorial Board Member (also 1995-96)
2001-2004 Co-Chair, American Heart Association Program Committee, Basic Sciences Council
2004-2005 - Chairman, NHLBI Clinical and Integrative Cardiovascular Sciences (CICS) Study Section
2006 -2007  Chairman, NHLBI Special Emphasis Panel Cardiovascular Diseases
2006-2008 Vice-Chair, Basic and Cardiovascular Science Council Steering Committee
2007-2009 Chair, Scientific Publishing Committee, American Heart Association
2008-2010 Member, Publications Committee, American Physiological Society
2008-2011  Member, Board of Regents, American College of Chest Physicians
2009         President Designee, American College of Chest Physicians
2009-2012 APS Representative, FASEB Publications and Communications Committee
2009-2012  Member, Scientific Sessions Program Committee, American Heart Association

Honors
1983-1985       NIH National Research Service Award
1986-1991       NIH Clinical Investigator Award
1994-1999       Established Investigator Award - American Heart Association
2004                Association of University Cardiologists, member
2008                George E. Brown Memorial Lecture, American Heart Association

• Additional recent publications of importance to the field (in chronological order)
  Liu Y, Bubolz AH, Shi Y, Newman PJ, Newman DK, Gutterman DD.  Peroxynitrite reduces the endothelium-derived hyperpolarizing factor component of coronary flow-mediated dilation in PECAM-1-knockout mice. Am J Physiol Regul Integr Comp Physiol 2006 Jan;290(1):R57-65.
• Guyatt G, Gutterman DD, Baumann MH, Addrizzo-Harris D, Hylek EM, Phillips B, Raskob G, Lewis SZ, Schünemann H. Grading strength of recommendations and quality of evidence in clinical guidelines:  report from an American College of Chest Physicians task force.  Chest. 2006 Jan;129(1): 174-81.
• Guyatt G, Baumann M, Pauker S, Halperin J, Maurer J, Owens DK, Tosteson AN, Carlin B, Gutterman DD, Prins M, Lewis SZ, Schünemann H. Addressing resource allocation issues in recommendations from clinical practice guideline panels:  suggestions from an American College of Chest Physicians task force.  Chest. 2006 Jan;129(1):182-7.
• Larsen BT, Miura H, Hatoum OA, Campbell WB, Hammock BD, Zeldin DC, Falck JR, Gutterman DD. Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BKCa channels:  implications for soluble epoxide hydrolase inhibition. Am J Physiol Heart Circ Physiol 2006 Feb;290(2): H491-9. PMCID: PMC1456013
• Hatoum OA, Otterson MF, Kopelman D, Miura H, Sukhotnik I, Larsen BT, Selle RM, Moulder JE, Gutterman DD. Radiation induces endothelial dysfunction in murine intestinal arterioles via enhanced production of reactive oxygen species.  ATVB 2006 Feb;26(2):287-94.
• Dedkov EI, Perloff JK, Tomanek RJ, Fishbein MC, Gutterman DD.  The coronary microcirculation in cyanotic congenital heart disease. Circulation 2006 Jul 18;114(3):196-200.
• Jurva JW, Phillips SA, Syed AQ, Syed AY, Pitt S, Weaver A, Gutterman DD. The effect of exertional hypertension evoked by weight lifting on vascular endothelial function.  JACC 2006 Aug 1;48(3):588-9.
• Dhanasekaran A, Al-Saghir R, Lopez B, Zhu D, Gutterman DD, Jacobs ER, Medhora M. Protective effects of epoxyeicosatrienoic acids on human endothelial cells from the pulmonary and coronary vasculature. Am J Physiol Heart Circ Physiol 2006 Aug;291(2):H517-31.
• Phillips SA, Hatoum OA, Gutterman DD. The mechanism of flow-induced dilation in human adipose arterioles involves hydrogen peroxide during CAD. Am J Physiol Heart Circ Physiol 2007 Jan;292(1):H93-100.
• Baumann MH, Lewis SZ, Gutterman DD. ACCP evidence-based guideline development: a successful and transparent approach addressing conflict of interest, funding, and patient-centered recommendations. Chest 2007 Sep;132(3): 1015-24.
• Bubolz AH, Wu Q, Larsen BT, Gutterman DD, Liu Y. Ebselen reduces nitration and restores voltage-gated potassium channel function in small coronary arteries of diabetic rats. Am J Physiol Heart Circ Physiol 2007 Oct;293(4): H2231-7. 
• Hoch AZ, Jurva JW, Staton MA, Thielke R, Hoffmann RG, Pajewski N, Gutterman DD. Athletic amenorrhea and endothelial dysfunction.  WMJ 2007 Sep;106(6):301-6.
• Phillips SA, Jurva JW, Syed AQ, Syed AQ, Kulinski JP, Pleuss J, Hoffmann RG, Gutterman DD. Benefit of low-fat over low-carbohydrate diet on endothelial health in obesity. Hypertension 2008 Feb;51(2):376-82.  PMCID: PMC2702133.  Winner of the Award for Most Significant Original Paper for 2008 in the category of Clinical Science.
• Larsen BT, Gutterman DD, Sato A, Toyama K, Campbell WB, Zeldin DC, Manthati VL, Falck JR, Miura H.  Hydrogen peroxide inhibits cytochrome P450 epoxygenases: interaction between two endothelium-derived hyperpolarizing factors.  Circ Res 2008 Jan 4;102(1): 59-67. PMCID: PMC2364729
• Mio Y, Bienengraeber MW, Marinovic J, Gutterman DD, Rakic M, Bosnjak ZJ, Stadnicka A.  Age-related attenuation of isoflurane preconditioning in human atrial cardiomyocytes: roles for mitochondrial respiration and sarcolemmal adenosine triphosphate-sensitive potassium channel activity.  Anesthesiology 2008 Apr;108(4):612-20.  PMCID: PMC2697447
• Liu Y, Li H, Bubolz AH, Zhang DX, Gutterman DD.  Endothelial cytoskeletal elements are critical for flow-mediated dilation in human coronary arterioles. Med Biol Eng Comput 2008 May;46(5):469-78.  PMCID: PMC2702135
• Toyama K, Wulff H, Chandy KG, Azam P, Raman G, Saito T, Fujiwara Y, Mattson DL, Das S, Melvin JE, Pratt PF, Hatoum OA, Gutterman DD, Harder DR, Miura H. 
• The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans.  J Clin Invest 2008 Sep;118(9):3025-37. PMCID: PMC2496961
• Farrell RM, Syed A, Syed A, Gutterman DD. Effects of limb electrode placement on the 12- and 16-lead electrocardiogram. J Electrocardiol  2008 Nov-Dec;41(6):536-45.
• Zhang DX, Mendoza SA, Bubolz AH, Mizuno A, Ge ZD, Li R, Warltier DC, Suzuki M, Gutterman DD.  Transient receptor potential vanilloid type 4-deficient mice exhibit impaired endothelium-dependent relaxation induced by acetylcholine in vitro and in vivo. Hypertension 2009 Mar;53(3):532-8. PMCID: PMC2694062
• Hoch AZ, Pajewski NM, Hoffman RG, Schimke JE, Gutterman DD. Possible relationship of folic acid supplementation and improved flow-mediated dilation in premenopausal, eumenorrhiec athletic women. J Sports Science & Medicine 2009 Mar;8(1):123-9.
• Larsen BT, Bubolz AH, Mendoza SA, Pritchard KA Jr, Gutterman DD.  Bradykinin-induced dilation of human coronary arterioles requires NADPH oxidase-derived reactive oxygen species.  ATVB 2009 May;29(5):739-45.  PMCID: PMC2727937
• Bodiga S, Zhang R, Jacobs DE, Larsen BT, Tampo A, Manthati VL, Kwok WM, Zeldin DC, Falck JR, Gutterman DD, Jacobs ER, Medhora MM.  Protective actions of epoxyeicosatrienoic acid: Dual targeting of cardiovascular PI3K and KATP channels. J Mol Cell Cardiol. 2009 Jun;46(6):978-88. PMCID: PMC2796716
  Migrino RQ, Hari P, Gutterman DD, Bright M, Truran S, Schlundt B, Phillips SA.  Systemic and microvascular oxidative stress induced by light chain amyloidosis.  Int J Cardiol 2009 May 14.  In press.
• Hoch AZ, Pajewski NM, Moraski L, Carrera GF, Wilson CR, Hoffmann RG, Schimke JE, Gutterman DD. Prevalence of the female athlete triad in high school athletes and sedentary students. Clin J Sport Med. 2009 Sep;19(5):421-8.  PMCID: In Process
• Mendoza SA, Fang J, Gutterman DD, Wilcox DA, Bubolz AH, Li R, Suzuki M, Zhang DX. TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress. Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H466-76.   PMCID: PMC2822567
• Hoch AZ, Lynch SL, Jurva JW, Schimke JE, Gutterman DD. Folic acid supplementation improves vascular function in amenorrheic runners. Clin J Sport Med.  2010 May;20(3):205-10.
• Ongoing Research Support
  R01 HL094971-01    Gutterman (PI)               1/1/09 – 12/31/12
  NIH/NHLBI
• Project Title: Role of Hydrogen Peroxide in the Mechanism of Flow-Induced Dilation of the Human Coronary Microcirculation
  This project examines the role of endothelial-derived mitochondrial ROS, specifically hydrogen peroxide, and oxidative modification of smooth muscle PKG in mediating flow-induced vasodilation.
  Role:  PI
• R01 HL080704 Gutterman (PI)1/1/06 – 12/31/10 NIH/NHLBI
  Project Title: Flow-Mediated Dilation of Human Coronary Arterioles.
  This project examines the role of mitochondria in flow-induced dilation of human coronary arterioles focusing on the role of the cytoskeleton and the influence of nitric oxide.
  Role:  PI
• K30 HL04112-01 Dunn (PI)1/1/06 – 12/31/11 NIH/NHLBI
  Project Title:  Clinical Research Curriculum Award
  The K-30 Program is an institutional grant to develop curriculum in clinical research.
  Role:  Program Faculty
• K23 HL085614 Phillips (PI)7/1/07 – 6/30/12
  Project Title:  Mechanisms of exertional hypertension and vascular dysfunction.
  This project’s goal is to determine the mechansims of vascular dysfunction induced by single episodes of exertional hyertension.
  Role:  Sponsor/Mentor
• AHA 9204906Zhang (PI) 1/1/08 – 12/31/11
  SDG
  Project Title: Endothelial TRPV4 channels in flow-mediated dilation
  The aim of this project is to examine the role of endothelial transient receptor potential V4 (TRPV4) channels in shear-induced signal transduction in endothelial cells and flow-mediated dilation of human coronary arterioles and mouse vessels.
  Role:  Mentor
• AHA 0855683G Migrino (PI)  7/1/08 – 6/30/10
  Greater Midwest GIA
  Project Title: Vascular dysfunction and oxidative stress in primary amyloidosis.
  The study aims to measure the effects of acute exposure on human adipose and coronary arterioles of amyloid light chains isolated from AL amyloidosis patients.
  Role:  Co-Investigator
• 1K23 HL089326       Widlansky (PI)                7/1/09 – 6/30/14
  Project Title: Importance of Mitochondria in the Endothelial Dysfunction of Type 2 Diabetes
  The specific aims are to study vascular function by both non-invasive (ultrasound and tonometry) as well as by invasive assessment of arteriole function related to mitochondrial homeostatsis in humans with Type 2 diabetes.
  Role:  Sponsor/Mentor

Completed Research Support

VA Merit Review  Gutterman (PI) 1/01/04 – 1/15/09
Project Title:  Role of EETs in the Regulation of the Human Coronary Microcirculation.
This project examines the role of EETs, proposed to be an EDHF in flow-induced vasodilation and agonist mediated vasodilation in the human coronary microcirculation.
Role:  PI

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